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KMID : 1098420070150050324
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 5 p.324 ~ p.328
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In-vitro Anti-inflammatory Activity of Rubus coreanus Miq. on Nitric Oxide, , Cycloxygenase-2, and Tumor Necrosis Production in the Macrophage like Cell Line RAW 264.7 Activated by Lipopolysccharide
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Choi Se-Young
Jeoung Young-Jun
Lim Beong-Ou
Lee Kyou-Chae
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Abstract
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To search for immunoactive natural products exerting anti-inflammatory activity, we have evaluated the effects of the ethanol extracts of Rubus coreanus Miq. (ERC) on lipopolysaccharide-induced nitric oxide (NO), tumor necrosis , and production by RAW 264.7 macrophage cell line. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased production. Consistent with these results, the protein level of inducible Nitric Oxide Synthase (iNOS) and cyclooxygenase-2 (COX-2) was inhibited by ethanol extracts of ERC in a dose-dependent manner. These results suggest that ERC may exert anti-inflammatory and analgesic effects possibly by suppressing the inducible NO synthase and COX-2 expressions.
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KEYWORD
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Rubus coreanus Miq., nitric oxide, iNOS
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